Management

C. Randal Mills, Ph.D.
Director, President and Chief Executive Officer

C. Randal Mills, Ph.D., President and Chief Executive Officer, began his service for Osiris in July 2004. Dr. Mills is also a member of the Board of Directors. Prior to joining Osiris, Dr. Mills was an executive officer of Regeneration Technologies, Inc. (NASDAQ—RTIX). Dr. Mills served in several leadership positions at RTI from its formation in 1998 until 2004, including Vice President of Business Development and Vice President of Operations and R&D and is credited with several key initiatives including the development and commercialization of RTI's core technology, BioCleanse®. Prior to RTI, Dr. Mills was a member of the founding management team of the University of Florida Tissue Bank, Inc. The University of Florida Tissue Bank was the predecessor company to RTI. Dr. Mills received a bachelor's degree in microbiology and cell science and a Ph.D. in drug development, both from the University of Florida.

Harry E. Carmitchel
Chief Operating Officer

Harry E. Carmitchel , Chief Operating Officer, joined Osiris in September 2004. Mr. Carmitchel has over 20 years of general management and operations experience in the medical field. Prior to joining Osiris, Mr. Carmitchel was a Principal with the Pacific Consulting Group for four years, where he specialized in corporate turnarounds. Prior to this time, Mr. Carmitchel was a General Manager with McQuay International, running a $410 million group, and spent eight years as President of the Medical Division for Stryker Corporation. Previously, he also served as Vice President of Operations and Vice President of Marketing for Everest and Jennings, Inc. Mr. Carmitchel earned an M.B.A. from the University of Southern California and a Bachelors degree in electrical engineering from the General Motors Institute.

Phillip R. Jacoby, Jr.
Interim Chief Financial Officer and Corporate Secretary

Phillip R. Jacoby, Jr., Interim Chief Financial Officer and Corporate Secretary, joined Osiris in April 2005. Mr. Jacoby previously served as the Company's Controller and Chief Accounting Officer. From 1999 to 2004, Mr. Jacoby served as Vice President and Corporate Controller for FTI Consulting, Inc., a global business financial and economic consulting firm. Mr. Jacoby began his career with Arthur Andersen & Co. and earned his undergraduate degree in business and public administration from the University of Maryland

Earl R. Fender
Vice President and General Manager for Orthopedics

Earl R. Fender , Vice President and General Manager for Orthopedics, joined Osiris in June 2006. Prior to joining Osiris, Mr. Fender served for over ten years with DePuy Spine, a Johnson & Johnson company, holding positions as Vice President, Sales, U.S. President, and finally as Worldwide President. Under his direction DePuy Spine became the second largest spinal implant manufacturer in the world. Most recently Mr. Fender served as Worldwide Vice President, Public Policy, for the five global businesses of DePuy, Inc., leading and shaping DePuy's response to key external environmental issues. Mr. Fender's academic credentials include a B.A. in Business Administration from Thiel College and the completion of Harvard Business School's Program for Management Development.

Lode Debrabandere, Ph.D.
Vice President and General Manager for Inflammatory Diseases

Lode Debrabandere, Ph.D. , Vice President and General Manager for Inflammatory Diseases, joined Osiris in July 2006. Prior to joining Osiris, Dr. Debrabandere served for over four years with Bristol-Myers Squibb as Vice President for Strategic Marketing for Neuroscience and Infectious Diseases. He led the Neuroscience Unit and was the Global Brand Leader for Abilify™. Previously, Dr. Debrabandere led the Marketing department of UCB Pharma Inc., focusing in the areas of allergy/respiratory (Zyrtec™) and neurology (Keppra™). Prior to leading the Marketing department at UCB Pharma, Inc., Dr. Debrabandere held various roles at increasing levels of responsibility in the Research and Development department including the management of all clinical development activities in the U.S., Europe, and Japan. Dr. Debrabandere earned an M.B.A., a Ph.D. in pharmaceutical sciences, toxicology, and a Pharm. D. degree in pharmaceutical sciences, all from the University of Leuven, Belgium.

Michelle LeRoux Williams, Ph.D.
Vice President of Development

Michelle LeRoux Williams, Ph.D., Vice President of Development, joined Osiris in October 2001. Previously at Osiris, Dr. Williams served as Director of Orthopedics. In that role Dr. Williams was responsible for the development of Osteocel® from initial concept through market launch. In 2005, Osteocel became the world's first commercially available stem cell product. Additionally, Dr. Williams advanced the Chondrogen™ program from preclinical testing through human clinical evaluation. Prior to joining Osiris, Dr. Williams completed an NIH postdoctoral fellowship in tissue engineering at Columbia University, evaluating cellular constructs for the repair and regeneration of cartilage in arthritis patients. Dr. Williams earned a Bachelors degree in mechanical engineering from Rice University and a Ph.D. in biomedical engineering from Duke University.